Kazuo Kinoshita's Lab @ Shizuoka Graduate University of Public Health
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Publication

  1. Kinoshita, K., Shimizu, A., and Honjo, T.: "The membrane exons of the pseudo-g-chain gene of the human immunoglobulin are apparently functional and highly homologous to those of the g1 gene" Immunol Lett 27: 151-5, 1991. [PubMed]

  2. Kinoshita, K., Tashiro, J., Tomita, S., Lee, C. G., and Honjo, T.: "Target specificity of immunoglobulin class switch recombination is not determined by nucleotide sequences of S regions" Immunity 9: 849-58, 1998. [PubMed]
    This is my thesis study, from which everything started.

  3. Muramatsu, M., Sankaranand, V. S., Anant, S., Sugai, M., Kinoshita, K., Davidson, N. O., and Honjo, T.: "Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells" J Biol Chem 274: 18470-18476, 1999.

  4. Kinoshita, K., Lee, C.-G., Tashiro, J., Muramatsu, M., Chen, X.-C., Yoshikawa, K., and Honjo, T.: "Molecular mechanism of immunoglobulin class switch recombination". In Cold Spring Harbor Symposia on Quantitative Biology: Signaling & Gene Expression in the Immune System: Cold Spring Harbor Laboratory Press), 64: pp. 217-226, 1999.

  5. Kinoshita, K., and Honjo, T.: "Unique and unprecedented recombination mechanisms in class switching" Curr Opin Immunol 12: 195-8, 2000.

  6. Revy, P., Muto, T., Levy, Y., Geissmann, F., Plebani, A., Sanal, O., Catalan, N., Forveille, M., Dufourcq-Labelouse, R., Gennery, A., Tezcan, I., Ersoy, F., Kayserili, H., Ugazio, A. G., Brousse, N., Muramatsu, M., Notarangelo, L. D., Kinoshita, K., Honjo, T., Fischer, A., and Durandy, A.: "Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)" Cell 102: 565-75, 2000. [PubMed]

  7. Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., and Honjo, T.: "Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme" Cell 102: 553-63, 2000. [PubMed]

  8. Ono, S. J., Zhou, G., Tai, A. K., Inaba, M., Kinoshita, K., and Honjo, T.: "Identification of a stimulus-dependent DNase I hypersensitive site between the Ialpha and Calpha exons during immunoglobulin heavy chain class switch recombination" FEBS Lett 467: 268-72, 2000.

  9. Muto, T., Muramatsu, M., Taniwaki, M., Kinoshita, K., and Honjo, T.: "Isolation, tissue distribution and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene" Genomics 68: 85-88, 2000.

  10. Tashiro, J., Kinoshita, K., and Honjo, T.: "Palindromic but not G-rich sequences are targets of class switch recombination" Int Immunol 13: 495-505., 2001.

  11. Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., and Honjo, T.: "In situ class switching and differentiation to IgA producing cells in the gut lamina propria" Nature 413: 639-43., 2001.

  12. Kinoshita, K., and Honjo, T.: "Linking class-switch recombination with somatic hypermutation" Nat Rev Mol Cell Biol 2: 493-503., 2001. [PubMed]

  13. Lee, C. G., Kinoshita, K., Arudchandran, A., Cerritelli, S. M., Crouch, R. J., and Honjo, T.: "Quantitative regulation of class switch recombination by switch region transcription" J Exp Med 194: 365-74., 2001.

  14. Kinoshita, K., Harigai, M., Fagarasan, S., Muramatsu, M., and Honjo, T.: "A hallmark of active class switch recombination: transcripts directed by I promoters on looped-out circular DNAs" Proc Natl Acad Sci U S A 98: 12620-3., 2001.

  15. Chen, X., Kinoshita, K., and Honjo, T.: "Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class switch recombination" Proc Natl Acad Sci U S A 98: 13860-5., 2001.

  16. Nagaoka, H., Muramatsu, M., Yamamura, N., Kinoshita, K., and Honjo, T.: "Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin S? Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation" J. Exp. Med. 195: 529-534, 2002.

  17. Okazaki, I., Kinoshita, K., Muramatsu, M., Yoshikawa, K., and Honjo, T.: "The AID enzyme induces class switch recombination in fibroblasts" Nature 416: 340-345., 2002.

  18. Honjo, T., Kinoshita, K., and Muramatsu, M.: "MOLECULAR MECHANISM OF CLASS SWITCH RECOMBINATION: Linkage with Somatic Hypermutation" Annu Rev Immunol 20: 165-96, 2002.

  19. Bross, L., Muramatsu, M., Kinoshita, K., Honjo, T., and Jacobs, H.: "DNA double-strand breaks: prior to but not sufficient in targeting hypermutation" J Exp Med 195: 1187-92., 2002.

  20. Yoshikawa, K., Okazaki, I. M., Eto, T., Kinoshita, K., Muramatsu, M., Nagaoka, H., and Honjo, T.: "AID enzyme-induced hypermutation in an actively transcribed gene in fibroblasts" Science 296: 2033-6., 2002.

  21. Doi, T., Kinoshita, K., Ikegawa, M., Muramatsu, M., and Honjo, T.: "De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination" Proc. Natl. Acad. Sci. U. S. A. 100: 2634-2638, 2003.

  22. Okazaki, I., Yoshikawa, K., Kinoshita, K., Muramatsu, M., Nagaoka, H., and Honjo, T.: "Activation-Induced Cytidine Deaminase Links Class Switch Recombination and Somatic Hypermutation" Ann N Y Acad Sci 987: 1-8, 2003.

  23. Okazaki, I. M., Hiai, H., Kakazu, N., Yamada, S., Muramatsu, M., Kinoshita, K., and Honjo, T.: "Constitutive Expression of AID Leads to Tumorigenesis" J Exp Med 197: 1173-81, 2003. [PubMed]

  24. Ta, V. T., Nagaoka, H., Catalan, N., Durandy, A., Fischer, A., Imai, K., Nonoyama, S., Tashiro, J., Ikegawa, M., Ito, S., Kinoshita, K., Muramatsu, M., and Honjo, T.: "AID mutant analyses indicate requirement for class-switch-specific cofactors" Nat Immunol 4: 843-8, 2003.

  25. Eto, T., Kinoshita, K., Yoshikawa, K., Muramatsu, M., and Honjo, T.: "RNA-editing cytidine deaminase Apobec-1 is unable to induce somatic hypermutation in mammalian cells" Proc Natl Acad Sci U S A 100: 12895-8, 2003.

  26. Shinkura, R., Ito, S., Begum, N. A., Nagaoka, H., Muramatsu, M., Kinoshita, K., Sakakibara, Y., Hijikata, H., and Honjo, T.: "Separate domains of AID are required for somatic hypermutation and class-switch recombination" Nat Immunol 5: 707-12, 2004.

  27. Begum, N. A., Kinoshita, K., Muramatsu, M., Nagaoka, H., Shinkura, R., and Honjo, T.: "De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination" Proc Natl Acad Sci U S A 101: 13003-7, 2004.

  28. Begum, N. A., Kinoshita, K., Kakazu, N., Muramatsu, M., Nagaoka, H., Shinkura, R., Biniszkiewicz, D., Boyer, L. A., Jaenisch, R., and Honjo, T.: "Uracil DNA glycosylase activity is dispensable for immunoglobulin class switch" Science 305: 1160-3, 2004.

  29. Kotani, A., Okazaki, I. M., Muramatsu, M., Kinoshita, K., Begum, N. A., Nakajima, T., Saito, H., and Honjo, T.: "A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expression" Proc Natl Acad Sci U S A 102: 4506-11, 2005.

  30. Kinoshita, K., and Nonaka, T.: "The dark side of activation-induced cytidine deaminase: relationship with leukemia and beyond" Int J Hematol 83: 201-7, 2006. [PubMed][PDF]

  31. Muto, T., Okazaki, I. M., Yamada, S., Tanaka, Y., Kinoshita, K., Muramatsu, M., Nagaoka, H., and Honjo, T.: "Negative regulation of activation-induced cytidine deaminase in B cells" Proc Natl Acad Sci U S A 103: 2752-2757, 2006.

  32. Wakae, K., Magor, B. G., Saunders, H., Nagaoka, H., Kawamura, A., Kinoshita, K., Honjo, T., and Muramatsu, M.: "Evolution of class switch recombination function in fish activation-induced cytidine deaminase, AID" Int Immunol 18: 41-7, 2006.

  33. Ukai, A., Maruyama, T., Mochizuki, S., Ouchida, R., Masuda, K., Kawamura, K., Tagawa, M., Kinoshita, K., Sakamoto, A., Tokuhisa, T., and O-Wang, J.: "Role of DNA polymerase theta in tolerance of endogenous and exogenous DNA damage in mouse B cells" Genes Cells 11: 111-21, 2006.

  34. Kou, T., Marusawa, H., Kinoshita, K., Endo, Y., Okazaki, I. M., Ueda, Y., Kodama, Y., Haga, H., Ikai, I., and Chiba, T.: "Expression of activation-induced cytidine deaminase in human hepatocytes during hepatocarcinogenesis" Int J Cancer 120: 469-76, 2007. [PubMed]

  35. Kou, T., Marusawa, H., Endo, Y., Nakase, H., Fujii, S., Kinoshita, K., Fujimori, T., Honjo, T., and Chiba, T.: "Ectopic expression of activation-induced cytidine deaminase in ulcerative colitis-associated colorectal cancers" Gastroenterology 132: A633-A633, 2007.

  36. Kotani, A., Kakazu, N., Tsuruyama, T., Okazaki, I. M., Muramatsu, M., Kinoshita, K., Nagaoka, H., Yabe, D., and Honjo, T.: "Activation-induced cytidine deaminase (AID) promotes B cell lymphomagenesis in Emu-cmyc transgenic mice" Proc Natl Acad Sci U S A, 2007.

  37. Endo, Y., Marusawa, H., Kinoshita, K., Okazaki, I. M., Sakurai, T., Watashi, K., Shimotono, K., Honjo, T., Chiba, T.: "Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappa B signaling" Oncogene 26: 5587-95, 2007. [PubMed]

  38. Matsumoto, Y., Marusawa, H., Kinoshita, K., Endo, Y., Kou, T., Morisawa, T., Azuma, T., Okazaki, I. M., Honjo, T., Chiba, T.: "Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium" Nat Med 13: 470-6, 2007. [PubMed]

  39. Komori, J., Marusawa, H., Machimoto, T., Endo, Y., Kinoshita, K., Kou, T., Haga, H., Ikai, I., Uemoto, S., and Chiba, T.: "Activation-induced cytidine deaminase links bile duct inflammation to human cholangiocarcinoma" Hepatology 47: 888-896, 2008.

  40. Omi, N., Kiyokawa, E., Matsuda, M., Kinoshita, K., Yamada, S., Yamada, K., Matsushima, Y., Wang, Y., Kawai, J., Suzuki, M., Hayashizaki, Y., and Hiai, H.: "Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse" Exp Eye Res 86: 828-34, 2008.

  41. Tsuji, M., Suzuki, K., Kitamura, H., Maruya, M., Kinoshita, K., Ivanov, II, Itoh, K., Littman, D. R., and Fagarasan, S.: "Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin a generation in the gut" Immunity 29: 261-71, 2008.

  42. Tsuji, M., Suzuki, K., Kinoshita, K., and Fagarasan, S.: "Dynamic interactions between bacteria and immune cells leading to intestinal IgA synthesis" Seminars in Immunology 20: 59-66, 2008.

  43. Endo, Y., Marusawa, H., Kou, T., Nakase, H., Fujii, S., Fujimori, T., Kinoshita, K., Honjo, T., and Chiba, T.: "Activation-induced cytidine deaminase links between inflammation and the development of colitis-associated colorectal cancers" Gastroenterology 135: 889-98, 2008.

  44. Takai, A., Toyoshima, T., Uemura, M., Kitawaki, Y., Marusawa, H., Hiai, H., Yamada, S., Okazaki, I. M., Honjo, T., Chiba, T., and Kinoshita, K.:"A novel mouse model of hepatocarcinogenesis triggered by AID causing deleterious p53 mutations" Oncogene 28: 469-478, 2009. [PubMed]

  45. Nonaka, T., Doi, T., Toyoshima, T., Muramatsu, M., Honjo, T., and Kinoshita, K.:"Carboxy-terminal domain of AID required for its mRNA complex formation in vivo" Proc Natl Acad Sci U S A 106: 2747-2751, 2009.

  46. Kobayashi, M., Aida, M., Nagaoka, H., Begum, N. A., Kitawaki, Y., Nakata, M., Stanlie, A., Doi, T., Kato, L., Okazaki, I. M., Shinkura, R., Muramatsu, M., Kinoshita, K., and Honjo, T.: "AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination" Proc Natl Acad Sci U S A 106: 22375-80, 2009.

  47. Shivarov, V., Shinkura, R., Doi, T., Begum, N. A., Nagaoka, H., Okazaki, I. M., Ito, S., Nonaka, T., Kinoshita, K., and Honjo, T.: "Molecular mechanism for generation of antibody memory" Philos Trans R Soc Lond B Biol Sci 364: 569-75, 2009.

  48. Uemura, M., Niwa, Y., Kakazu, N., Adachi, N., and Kinoshita, K.: "Chromosomal manipulation by site-specific recombinases and fluorescent protein-based vectors" PLoS ONE 5: e9846, 2010. [PubMed][Article]

  49. Matsumoto, Y., Marusawa, H., Kinoshita, K., Niwa, Y., Sakai, Y., and Chiba, T.,: "Upregulation of activation-induced cytidine deaminase causes genetic aberrations at the CDKN2b-CDKN2a in gastric cancer" Gastroenterology 139: 1984-94, 2010. [PubMed]

  50. Irino, T., Uemura, M., Yamane, H., Umemura, S., Utsumi, T., Kakazu, N., Shirakawa, T., Ito, M., Suzuki, T., and Kinoshita, K.: "JAK2 V617F-dependent upregulation of PU.1 expression in the peripheral blood of myeloproliferative neoplasm patients" PLoS ONE 6: e22148, 2011. [PubMed][Article]

  51. Takai, A., Marusawa, H., Minaki, Y., Watanabe, T., Nakase, H., Kinoshita, K., Tsujimoto, G., Chiba, T.: "Targeting activation-induced cytidine deaminase prevents colon cancer development despite persistent colonic inflammation" Oncogene 31: 1733-42, 2012. [PubMed]

  52. Nguyen, T., Xu, J., Chikuma, S., Hiai, H., Kinoshita, K., Moriya, K., Koike, K., Marcuzzi, G. P., Pfister, H., Honjo, T., and Kobayashi, M.: "Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models" Int Immunol 26: 397-406, 2014. [PubMed]

  53. Kitamura, J., Uemura, M., Kurozumi, M., Sonobe, M., Manabe, T., Hiai, H., Date, H., and Kinoshita, K.: "Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer" PLoS One 10: e0117986, 2015. [PubMed] [Article]

  54. Liang, G., Liu, G., Kitamura, K., Wang, Z., Chowdhury, S., Monjurul, A. M., Wakae, K., Koura, M., Shimadu, M., Kinoshita, K., and Muramatsu, M.: "TGF-beta Suppression of HBV RNA through AID-Dependent Recruitment of an RNA Exosome Complex" PLoS Pathog 11: e1004780, 2015. [PubMed] [Article]

  55. Nonaka, T., Toda, Y., Hiai, H., Uemura, M., Nakamura, M., Yamamoto, N., Asato, R., Hattori, Y., Bessho, K., Minato, N., and Kinoshita, K.: "Involvement of activation-induced cytidine deaminase in skin cancer development" J Clin Invest 126: 1367-82, 2016. [PubMed] [Article]

  56. Yamahara, K., Nakagawa, T., Ito, J., Kinoshita, K., Omori, K., and Yamamoto, N.: "Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells" Neuropharmacology 119: 26-39, 2017. [PubMed]

  57. Liu, J., Xiong, E., Zhu, H., Mori, H., Yasuda, S., Kinoshita, K., Tsubata, T., and Wang, J. Y.: "Efficient Induction of Ig Gene Hypermutation in Ex Vivo-Activated Primary B Cells" J Immunol 199: 3023-3030, 2017. [PubMed]

  58. Matsumoto, T., Takai, A., Eso, Y., Kinoshita, K., Manabe, T., Seno, H., Chiba, T., and Marusawa, H.: "Proliferating EpCAM-Positive Ductal Cells in the Inflamed Liver Give Rise to Hepatocellular Carcinoma" Cancer Res 77: 6131-6143, 2017. [PubMed]

  59. Zong, C., Kimura, Y., Kinoshita, K., Takasu, S., Zhang, X., Sakurai, T., Sekido, Y., Ichihara, S., Endo, G., and Ichihara, G.: "Exposure to 1,2-dichloropropane upregulates the expression of activation-induced cytidine deaminase (AID) in human cholangiocytes co-cultured with macrophages" Toxicol Sci, 2018. [PubMed]

  60. Komabayashi-Suzuki, M., Yamanishi, E., Watanabe, C., Okamura, M., Tabata, H., Iwai, R., Ajioka, I., Matsushita, J., Kidoya, H., Takakura, N., Okamoto, T., Kinoshita, K., Ichihashi, M., Nagata, K. I., Ema, M., and Mizutani, K. I.: "Spatiotemporally Dependent Vascularization Is Differently Utilized among Neural Progenitor Subtypes during Neocortical Development" Cell Rep 29: 1113-1129 e5, 2019. [PubMed]

  61. Kinoshita, K., Uemura, M., Shimizu, T., Kinoshita, S., and Marusawa, H.: "Stepwise generation of AID knock-in and conditional knockout mice from a single gene-targeting event" Int Immunol 33: 387-398, 2021. [PubMed][Ariticle][PDF]

  62. Takizawa, R., Ichihara, S., Zong, C., Kinoshita, K., Sakurai, T., Ikegami, A., Mise, N., and Ichihara, G.: "1,2-Dichloropropane induces gamma-H2AX expression in human cholangiocytes only in the presence of macrophages" Toxicol Lett 349: 134-144, 2021.[PubMed]

  63. Ekuban, A., Zong, C., Ekuban, F. A., Kimura, Y., Takizawa, R., Morikawa, K., Kinoshita, K., Ichihara, S., Ohsako, S., and Ichihara, G.: "Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro" Toxics 9, 2021.[PubMed]

  64. Ekuban, A., Shichino, S., Zong, C., Ekuban, F. A., Kinoshita, K., Ichihara, S., Matsushima, K., and Ichihara, G.: "Transcriptome analysis of human cholangiocytes exposed to carcinogenic 1,2-dichloropropane in the presence of macrophages in vitro" Sci Rep 12: 11222, 2022. [PubMed]

  65. Matsunuma, R., Sato, S., Chan, J. Y., Kinoshita, K., Taku, K., Yamaguchi, K., Hayami, R., Arai, K., Suzuki, M., and Tsuneizumi, M.: "Enrichment of Immune-Related Genes in Aggressive Primary Breast Angiosarcoma: A Case Report" Case Rep Oncol 16: 455-464, 2023. [PubMed]

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